1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.
2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf
4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36
5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs
ixieellectualacksley.com. canadaphil.https://www.ixie intellectualacksley.com/ [Accessed on November 08th, 2023]ixiecentric. energy.https://www.ixie.com.in/product/556/ixiecentricGiulianooodoo.https://www.haple.org.uk/product/ Giulianooodoo_full PLoSunder..
Centura.https://www.centura.com/product/ CenturaCipla.https://www.iplasys.com/product/Cipla-OLSDate/Cipla-OLSDate-OLSDate.pdf
Maltosum.https://www.altos.com/product/altos/Maltos/Maltos.pdfMethamphetamine.https://www.fda.gov/anthemade/STYLE/STYLE_STtold.html
Tadalafil.https://www.tadalafil-strengthening.co.uk/product/Cialis-OLSDate-OLSDate-OLSDate.shg
Vardenafil.https://discountline.com/discount/vetenate
Tejal.https://www.urology.com/Abstract_asu-20.htmlPulmonary arterial hypertension (PAH) is a chronic disease that affects approximately 1 in 100 people in the UK. The optimal treatment is not fully understood, but it is thought to occur in response to physical symptoms or exercise. The most common causes of PAH are high blood pressure in the lungs (hypertension), high blood pressure in the heart (PAH), high blood pressure in the leg (PAHTLE), and a condition called peripheral vascular disease. The symptoms of PAH include chest tightness, wheezing, shortness of breath, and feeling faint or lightheaded. These symptoms are usually short-term and are usually mild and subside with increasing blood pressure.
Tadalafil is an oral PDE5 inhibitor. It works by relaxing the blood vessels in the penis, improving blood flow.
Before we explain how Tadalafil helps manage ED, we need to explain how erections occur naturally. When you become aroused, your body releases a substance called nitric oxide (NO). In turn, levels of a chemical known as cyclic guanosine monophosphate (cGMP) increase in your body, relaxing the muscles on the sides of your penis so blood can flow into the organ and trigger a stiff erection.
While all this is happening, your body also compresses the veins that take blood away from your penis. This increased blood flow causes a slight increase in blood pressure. Eventually, the red blood your body has with tadalafil is used using it to help prevent you getting an extremely low ED risk prostate-related side effect called penile fibrosis (androgens deficiency).
If you already have an ED negative fibro type, you can also get ED treatments such asErectile Dysfunction Drugs(PDE-50 inhibitors) or
These medications have been proven to help you achieve and maintain an erection.
If you’re already taking medications for ED or have any medications you may be taking regarding ED, you can take Tadalafil to help treat both.
How to Use Tadalafil
As this is a medication, you should always follow the instructions given to you by your doctor or pharmacist. All medications are taken orally with or without food. You should take Tadalafil about 1 hour before sexual activity so that the medication can take this effect for best results.
As this substance is already present in the blood stream it helps increase the levels of cGMP by regulating the flow of cGMP into the penis.
As cyclic alkylates it on the same molecule it releases into your bloodstream cGMP on a separate level called the smooth muscle. When cGMP is phosphorylated on one of the two proteins on the smooth muscle that controls the blood flow into the penis, it creates an erection.
When tadalafil is taken it may help increase the levels of cGMP in the penis. This increase can help keep you able to get an erection even on the very rare occasion when it does not occur.
If you take too much tadalafil then you may experiencepenile fibro type 2 (pnex to penile fibro type 2)andandrogen (androgenic alopecia)inability to get an erection. If you take too much tadalafil, you may experiencepenile fibro type 1 (pne to penile fibro type 1)This condition can be caused in many ways, but the most common is by taking a high dose of tadalafil. When you take tadalafil, the medication may cause a dangerous drop in blood pressure. So, so high a dose of tadalafil is taken and you have a risk of dizziness, headaches, and other side effects. If you take tadalafil along with a high dose of tadalafil, then you may experiencehigh blood pressure, dizziness, and more. This condition can be caused in many ways including by taking a medication such as riociguat (Adempas) or by taking any other blood pressure medication. Just because you take a high dose of tadalafil does not mean that you have a medical condition that may be associated with the use of this medication.
If you take riociguat or other other medications for ED, you may also need to discuss with your doctor how Tadalafil may affect your ability to get an erection. This discussion is with your doctor before you start taking any medications.
If you take riociguat or any other medications for ED or have any medical conditions, you should always follow the instructions provided by your doctor or pharmacist. This includes any medications you are taking currently and any herbal supplements you have ever experienced with tadalafil. And always use the lowest effective dose for the shortest possible time.
If you’re not sure about the dosage and have any questions, ask your doctor or pharmacist.
Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.
Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.
You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.
Read the Patient Information Leaflet if you are taking tadalafil and understand the requirements as shown on the websiteTadalafil may cause dizziness and fainting commonly due to low blood pressure. If you experience these, get medical advice first. Do not drive or operate machinery until you know how you can affect yourself and your balance. Tadalafil should be taken with caution. Tadalafil may make you feel sick (see 'Side effects' below). If you can, avoid excessive heat exposure as it may cause an unconsciousness. Alcohol consumption may increase the chance of experiencing dizziness and fainting. Stop using Tadalafil and get medical advice once you have had had had a chance to feel well.
Do not take tadalafil if you are taking nitrates (used to treat angina). Nitrates can cause a dangerous drop in blood pressure. Before taking tadalafil, tell your doctor about your health condition, the medicines you are taking and your health condition. These can lead to a dangerous drop in blood pressure. Tadalafil should be taken only when needed, since Tadalafil may cause a drop in blood pressure. If you experience sudden vision loss, get medical advice first. If you experience dizziness, lightheadedness, fainting, dizziness, seizures, memory loss or confusion, stop taking tadalafil and try to stop taking it as soon as possible after. Do not drive or operate machinery until you have seen your doctor. Tadalafil may cause mild dizziness and fainting. Avoid driving or using machinery until you have gone over your limit or discussed your symptoms with your doctor. If you can, avoid excessive heat exposure as it may cause a unconsciousness. Stop taking tadalafil and seek medical advice once you have had had a chance to feel well.
The most common side effects of taking tadalafil are headache, nasal congestion, indigestion, dry mouth, headache, diaphoresis (flow problem), muscle pain, back pain, flushing, tiredness, stuffy or runny nose, muscle pain, nausea, stomach pain, dizziness, and vomiting. If these side effects last, or get in the eyes or][b] get medical advice, get up slowly, and do not exceed the recommended dose.
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Ex. mianshikum, Sildenafil (sildenafil) can affect theitability ofother medications. These medications should not be taken combined.
Cialis (tadalafil) can interact with certain foods and beverages, such as grapefruit and grapefruit juice, and may cause a rise in blood pressure by inhibiting protease. Cold and allergy-friendly foods like chocolate, fruit, and grapefruit may interact with Cialis. If you are taking Cialis with a hot and cold medicine, consider using anhydrous nitrates (Ex. isosorbide mononitrate or isosorbide dinitrate) to mitigating this effect.
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